Glowing


The Glowing study (clinicaltrials.gov identifier: NCT01131117) is an ongoing longitudinal observational study of normal weight, overweight and obese mothers and their offspring. In Glowing, women who already had one child are followed carefully throughout pregnancy and their children are followed during their first 2 years of life. We have successfully recruited all participants (300 women) from the Central Arkansas region. As of June 2015, 23 children will have completed the study. The retention rate for this 3-year study is currently 73%. The study will be completed in August 2017.

Publications

Ou X, Thakali K, Shankar K, Andres A, Badger TM. Maternal Adiposity Negatively Influences Infant Brain White Matter Development. Obesity In Press

Saben J, Kang P, Zhong Y, Thakali KM, Gomez-Acevedo H, Borengasser SJ, Andres A, Badger TM, Shankar K. RNA-seq Analysis of the Rat Placentation Site Reveals Maternal Obesity-Associated Changes in Placental and Offspring Thyroid Hormone Signaling. Placenta 2014 Dec;35(12):1013-20.

Thakali K, Saben J, Faske J, Lindsey F, Gomez-Acevedo H, Lowery Jr. C, Badger TM, Andres A, Shankar K. Maternal Obesity is Associated with Augmented Immediate-Early Gene Expression and Altered Insulin Sensitivity in Umbilical Cord. Pediatric Research. 2014 76(2):202-210

Saben J, Thakali KM, Lindsey FE, Zhong Y, Badger TM, Andres A, Shankar K. Distinct adipogenic differentiation phenotypes of human umbilical cord mesenchymal cells dependent on adipogenic conditions. Exp Biol Med 2014 239(10):1340-51.

Saben J, Forrest L, Zhong Y, Thakali K, Andres A, Badger TM, Gomez-Acevedo H, Shankar K. Maternal Obesity is Associated with a Lipotoxic Placental Environment. Placenta. 2014 35(3):171-177.

Saben J, Zhong Y, McKelvey S, Dajani NK, Andres A, Badger TM, Gomez-Acevedo H, Shankar K. A Comprehensive Analysis of the Human Placenta. Placenta. 2014 35(2):125-131.

Saben J, Zhong Y, Gomez-Acevedo H, Thakali KM, Borengasser SJ, Andres A, Shankar K. Early growth response protein-1 coordinates lipotoxicity-associated placental inflammation: role in maternal obesity. American Journal of Physiology – Endocrinology and metabolism. 2013 305(1):E1-14